How to Start Buprenorphine (Bup/Suboxone/Subutex) On Your Own

Medium-Dose Induction

This handout is meant to be a guide to help you start buprenorphine safely.

Please feel free to use your experience to safely start buprenorphine in a way that works for you.


Before you take any buprenorphine medication:

  1. Stop taking all opioids at least 12 hours before starting buprenorphine.
  2. Begin taking comfort medications if prescribed by your provider. Comfort medications are the medicines available for anxiety, nausea, muscle aches, etc.
  3. Keep waiting after the 12 hours until you start to feel withdrawal symptoms. If you don’t wait until you feel withdrawal symptoms, buprenorphine can make you feel sick.

Day 1 — Time to start

First dose:

  • When you begin to feel withdrawal symptoms, take your first dose of 8 mg buprenorphine under your tongue.
  • Keep medication under your tongue until fully dissolved
  • Do not eat or drink while it is dissolving
  • Wait one hour to see if the medication helps

1-hour after you dose:

Are you still feeling withdrawal symptoms?

Still feel sick » Take a second 8mg dose
Better » Wait 1 hour

2-hours after your first dose

Continue taking all comfort medications as prescribed.

If you still feel sick, text BLP at (866) 679-0831

How many doses did you take today?

1st dose: _____MG

2nd dose: _____MG

Total taken day: _____MG


Day 2

Take the full dose you took on Day 1 in the morning of Day 2.